At least that’s what Stefano Mazzocchi says (via Bob Walsh’s mISV Digest):

At the same time, I found the “960 Grid System“, a kind of “CSS Framework” that lets you easily create a homogeneous design through columns. It’s also good for prototyping.

The 960 Grid System is free to use, and may be adapted to meet your specific needs. Several projects have already spun off, including versions that were built to be fluid and elastic.

Check out a tutorial of the 960 Grid System, written by Adam Hawkins.

You can easily create a grid system using an online tool, at The Grid System Generator where you can simulate some designs. The site itself was built upon the grid system and looks great!

It’s no match to a good designer, and to use this system you still need to apply some design work and some good taste, but for those that want a simple and good looking solution, I hope this helps.